This study examines the impact of air pollution emissions on life expectancy in Uzbekistan, using panel data from 2011 to 2022. It assesses how air quality, alongside economic indicators, influences longevity. The findings indicate that increased air pollution significantly reduces life expectancy, with a one-million-ton rise in emissions decreasing life expectancy by about 5 years for males and 4 years for females. Economic factors such as GDP per capita positively affect life expectancy, while real income and the number of schools have varying impacts. Despite some insignificant results, the study suggests ongoing investment in environmental and educational improvements. Limitations include data constraints and methodological challenges, which could be addressed in future research. This study provides crucial insights into the complex relationship between air pollution and life expectancy, emphasizing the need for comprehensive policies to improve air quality and support economic development.