Telehealth and remote monitoring have revolutionized healthcare delivery by providing continuous, real-time patient care beyond traditional clinical settings. These technologies improve access to healthcare services, enhance chronic disease management, and reduce hospitalizations, ultimately contributing to better health outcomes. However, the success of telehealth relies significantly on patient perception and acceptance, which are influenced by multiple factors. This review explores the key determinants that shape patients' willingness to adopt telehealth and remote monitoring solutions, including technological, personal, psychological, and healthcare system-related factors. Ease of use, reliability, and integration with electronic health records (EHR) are critical technological factors affecting patient acceptance. Personal attributes such as age, education, digital literacy, and socioeconomic status also play a crucial role in determining the adoption of telehealth services. Additionally, psychological aspects, including trust in technology and healthcare providers, concerns about data privacy, and readiness for digital health engagement, influence patient perception. From a broader perspective, healthcare policies, insurance coverage, and provider support systems impact the widespread implementation and acceptance of telehealth solutions. Despite the benefits, challenges such as digital accessibility disparities, resistance from both patients and healthcare providers, technical limitations, and privacy concerns hinder the full integration of telehealth into routine care. To address these issues, strategies such as improving digital health literacy, enhancing telehealth platform usability, strengthening cybersecurity measures, and developing supportive policies are essential. This review presents case studies of successful telehealth implementations and discusses best practices for optimizing patient-centered remote care. Findings suggest that improving patient perception and acceptance of telehealth can lead to better adherence, higher patient engagement, and ultimately improved health outcomes. Moving forward, a multidisciplinary approach involving policymakers, healthcare providers, and technology developers is essential to maximize the benefits of telehealth and remote monitoring.