The purpose of this study was to find out the effect of Mathematics and Science Teaching Styles used by female facilitators on the academic performance of lower primary pupils in Kpone-Katamanso District. An overwhelmingly 96% of kindergarten and preschool facilitators (teachers) are women, according to a new report from the Wall Street Journal using 2023 data from the Bureau of Labor Statistics. This study focused on women because of these revealing statistics. The study used case study, non-probability and purposive sampling techniques in selecting the preschool facilitators in Kpone-Katamanso District to obtain data for the study. The sample size for the study was ten (10) female preschool facilitators. Interviews and questionnaires were the main data collection instruments used in this study. The data obtained were analyzed using content analysis, charts and percentages to find out the preschool facilitators’ dominant teaching styles in mathematics and science. The results reveal the various mathematics and science teaching styles adopted by female facilitators in the lower primary schools and the best mathematics teaching styles used. It was revealed that most preschool facilitators used blended teaching styles in teaching mathematics and science. This was evident in the years of teaching experience. Interview guides made it clear for these facilitators to explain how their teaching styles are helping improve the academic performance of the pupils beyond their class. It was recommended that the Lower Primary Facilitators adopt and make good use of Inquiry- Based Learning and Problem-Based Learning because they promote STEM teaching. Subject teachers should be employed to handle the lower primary mathematics and science. For effective teaching and learning in schools, teachers must take the following into considerations, learning styles, diverse needs, cultural backgrounds, and personality difference.